Non Government Organizations

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Simons Foundation Autism Research Initiative

Launched in 2005, the Simons Foundation Autism Research Initiative is a research campaign within the Simons Foundation's overall suite of programs. SFARI's mission is to improve the diagnosis and treatment of autism spectrum disorders by funding, catalyzing and driving innovative research of the greatest quality and relevance. RUCDR is proud to perform all aspects of biospecimens processing for both of the major SFARI projects.

The Simons Simplex Collection

The Simons Simplex Collection is a permanent repository of genetic samples from 2,700 families, each of which has one child affected with an autism spectrum disorder, and unaffected parents and siblings. Each genetic sample has an associated collection of data that provides a precise characterization of the individual (phenotype). Rigorous phenotyping maximizes the value of the resource for a wide variety of future research projects on the causes and mechanisms of autism.

The Simons Variation in Individuals Project

The Simons Variation in Individuals Project is a research initiative that aims to identify and study a large number of individuals with a recurrent genetic variation (deletion or duplication of segment 16p11.2) that increases the risk of developing autism spectrum and other neurodevelopmental disorders. The Simons VIP will collect detailed clinical information and blood samples from more than 200 carriers and their families, with the immediate goal of identifying medical, cognitive, neural and behavioral profiles shared by this genetically identified group. Careful analysis of genetically defined autism subtypes will allow detailed phenotypic comparisons within and among these groups to clarify genotype-phenotype correlations.


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